Hip-implant related chorio-retinal cobalt toxicity

Toxicity of cobalt-chromium nanoparticles released from a resurfacing hip implant and cobalt ions on primary human lymphocytes in vitro.

Adverse tissue responses to prostheses wear particles and released ions are important contributors to hip implant failure. In implant-related adverse reactions T-lymphocytes play a prominent role in sustaining the chronic inflammatory response. To further understand the involvement of lymphocytes in metal-on-metal (MoM) implant failure, primary human lymphocytes were isolated and treated with c...

Chorio-retinal hazards in aphakia.

We are taught-though it is impossible to establish on what authority-that the human crystalline lens specifically protects the retina and choroid from thermal damage. To be more precise: if a glass blower has had a lens removed because of a radiation cataract he is advised not to return to his job. It seems, however, that, if his vision can be restored to enable him to resolve all the necessary...

Molecular analysis of chromium and cobalt-related toxicity

Occupational and environmental exposure to Co and Cr has been previously linked to a wide array of inflammatory and degenerative conditions and cancer. Recently, significant health concerns have been raised by the high levels of Cr and Co ions and corrosion products released by biomedical implants. Herein, we set to analyze the biological responses associated with Co and Cr toxicity. Histologic...

Occlusion of the posterior ciliary artery. II. Chorio-retinal lesions.

The clinical picture of central retinal artery occlusion is well-known. Little is known, however, about the clinical picture of occlusion of the posterior ciliary arteries (PCAs). We have, therefore, carried out experimental occlusion of the various PCAs individually or together in rhesus monkeys. The effects of such occlusions have been investigated in the choroid, pigment epithelium (PE), and...

Disturbance of the chorio-capillaris and retinal dehiscence.